Longevity & Optimisation

LathMized™ NAD+
Longevity Protocol

After 40, your body produces over 50% less NAD+ — the molecule that powers every cell, repairs your DNA, and keeps your metabolism sharp. The fatigue, the slower recovery, the brain fog that wasn't there before — this is the cellular reason. The Longevity Protocol addresses it at the root with the most direct oral NAD+ delivery available, clinically confirmed to raise intracellular NAD+ by 53% in 5 days.

2-Phase Protocol Practitioner Supervised RCT-Backed Formula Most Popular

Longevity & Optimisation Protocol·Cellular Energy·Cognitive Sharpness·DNA Repair·Metabolic Efficiency·Healthy Ageing·2-Phase Programme·Practitioner Supervised·NCT07336836·Ships UK · EU · US · Canada·Longevity & Optimisation Protocol·Cellular Energy·Cognitive Sharpness·DNA Repair·Metabolic Efficiency·Healthy Ageing·2-Phase Programme·Practitioner Supervised·NCT07336836·Ships UK · EU · US · Canada·

53^%

Intracellular NAD+
increase · 5 days

100^%

Participants
responded

32^%

SIRT1 longevity
protein increase

Serious adverse
events recorded

This protocol is designed for

Is this right for you?

You're in your 30s, 40s or 50s and you can feel the change — your energy isn't what it was, your recovery takes longer, your thinking is slightly less sharp. You're not ill. You're declining. And you want to do something about it before the gap widens.

You've used NMN or NR precursors — these rely on multi-step enzymatic conversion pathways that are rate-limited and decline with age. LathMized™ is designed to support intracellular NAD+ levels directly, rather than relying on precursor conversion.

You optimise seriously — you track your sleep, your metabolic markers, your cognition. You want a supplement backed by a published double-blind RCT with measurable intracellular endpoints, not a marketing claim.

Your recovery from exercise or stress is slower than it used to be — this is one of the earliest and most reliable signals of declining NAD+. Mitochondrial efficiency falls, ATP production takes longer, and the body simply doesn't bounce back the way it did.

You're thinking about longevity seriously for the first time — not as a vague idea but as a practical programme. You want a structured, supervised starting point that gives you the cellular foundation everything else builds on.

You're managing multiple supplements and nothing is moving the needle — NAD+ is foundational. It's the cofactor for over 500 enzymatic reactions. Without it at adequate levels, many other interventions are working against a cellular energy deficit.

What this protocol supports

Key clinical benefits

All claims are based on statistically significant biomarker changes from the RENEWAL-NAD+ placebo-controlled double-blind RCT (NCT07336836).

Cellular Energy & Mitochondrial Output

NAD+ is the rate-limiting cofactor for mitochondrial ATP production. Phase 1 raises intracellular NAD+ by 53% in 5 days — directly restoring the cellular fuel production that naturally declines from your 30s onwards.

Cognitive Sharpness & Mental Clarity

The trial showed significant upregulation of neuroprotective proteins and serotonin signalling markers. The subjective experience most members report first is cognitive — faster recall, clearer thinking, fewer mental energy crashes in the afternoon.

DNA Repair & Genomic Integrity

NAD+ is the essential substrate for PARP enzymes, which repair oxidative DNA damage. Without adequate NAD+, the repair backlog compounds with age — contributing to accelerated cellular dysfunction across every tissue.

SIRT1 & Longevity Pathways

The RENEWAL-NAD+ trial confirmed a 32% increase in SIRT1 expression. SIRT1 is one of the primary sirtuin proteins that regulates cellular stress response, metabolic efficiency, and inflammatory signalling — core to biological ageing.

Physical Recovery & Metabolic Efficiency

Trial data showed significant improvements across metabolic pathways relevant to exercise recovery — lipid metabolism, glucose regulation, and oxidative stress markers. Most members notice faster recovery from exertion in the first few weeks.

9 of 12 Hallmarks of Ageing

The RENEWAL-NAD+ trial showed positive impact across 9 of the 12 clinically recognised hallmarks of ageing — including mitochondrial dysfunction, genomic instability, cellular senescence, and dysregulated nutrient sensing.

All benefits listed reflect statistically significant biomarker changes from the RENEWAL-NAD+ placebo-controlled double-blind RCT (NCT07336836) — conducted with the Institute of Systems Biology and published on bioRxiv 2026. Peer review pending.

Your membership includes

What you receive

Every element of this protocol — including the full dosing schedule, product supply and practitioner support — is available exclusively to Harmover members.

Practitioner Assessment

A Harmover practitioner reviews your health summary and current supplement stack before approving protocol access — ensuring the dosing is appropriate for you specifically.

Full Protocol Access

Your complete 2-phase dosing schedule and administration guide — Phase 1 powder instructions and Phase 2 sublingual tablet guidance — released in your member dashboard on approval.

LathMized™ NAD+ Products

Phase 1 powder for 10-day high-intensity repletion and Phase 2 sublingual tablets for long-term daily maintenance — both shipped after purchase.

Ongoing Practitioner Support

Regular check-ins and practitioner messaging throughout the protocol — available via your member dashboard for questions at any phase.

Purchase options

Get the products for this protocol

The Longevity Protocol uses LathMized™ Powder for the first 10 days (Phase 1), then sublingual tablets for long-term daily maintenance (Phase 2). All products require member registration and practitioner approval.

Complete bundle Best Value

Complete Longevity & Optimisation Kit

Powder + Tablets — both phases

Both phase products together — the Phase 1 powder for the 10-day repletion period and Phase 2 tablets for ongoing daily maintenance. Includes your full protocol document and practitioner support.

Phase 1 Powder included Phase 2 Tablets included Practitioner support included

Free registration · No commitment

Or purchase by phase individually

Phase 1 · High-Intensity Repletion

LathMized™ NAD+ Powder

Used in Phase 1 of the Longevity Protocol — 1,500mg/day dissolved in water and sipped hourly over 10 consecutive days. Mucosal absorption delivers NAD+ directly to cells. The format used in the RENEWAL-NAD+ trial.

Protocol dose

1,500mg/day · sipped hourly · 10 days

Phase 2 · Long-Term Maintenance

LathMized™ NAD+ Sublingual Tablets

Used in Phase 2 from Day 11 onwards — one 100mg sublingual tablet placed under the tongue each morning. Sustains the NAD+ levels established during Phase 1 repletion, indefinitely.

Protocol dose

100mg/day · AM · Day 11+

Members only

Access this protocol
through Harmover

This protocol — including the full dosing schedule, phase-by-phase administration guide, and product supply — is available exclusively to registered Harmover members.

Registration is free and takes less than two minutes. Once registered, a Harmover practitioner will review your health summary before releasing your personalised protocol access.

Register free — create your Harmover member account with basic health information

Practitioner review — a qualified Harmover practitioner reviews your health summary and approves protocol access

Receive your protocol — full dosing schedule, products shipped, and practitioner support activated through your member dashboard

Longevity & Optimisation

LathMized™ NAD+ Longevity & Optimization Protocol

Your membership includes

Practitioner-reviewed protocol access
Phase-appropriate LathMized™ NAD+ products
Full dosing schedule & administration guide
Ongoing practitioner support & check-ins

Free to register · No commitment · Ships UK · EU · US · Canada

Clinical evidence

Backed by a double-blind RCT

The RENEWAL-NAD+ study — conducted with the Institute of Systems Biology, approved by Western IRB (Protocol No. 20215675) — provides the clinical foundation for the LathMized™ platform.

"LathMized™ NAD+ achieved a 53% increase in intracellular NAD+ concentration in 5 days — with blood plasma NAD+ remaining unchanged, confirming cellular rather than circulatory delivery. 100% of participants responded. SIRT1 increased by 32%. 9 of 12 hallmarks of ageing were positively impacted. Zero serious adverse events across 60 participants aged 45–75."

RENEWAL-NAD+ RCT · NCT07336836 · bioRxiv 2026 · DOI: 10.64898/2026.03.25.714130

RENEWAL-NAD+ RCT · NCT07336836 · bioRxiv 2026 Read preprint ↗ ClinicalTrials.gov ↗

53^%

Intracellular NAD+
increase · 5 days

Biomarkers
significantly changed

9/12

Hallmarks of ageing
positively impacted

Serious adverse
events recorded

Common questions

Questions about the Longevity Protocol

Will I actually feel a difference?

The RENEWAL-NAD+ trial showed measurable intracellular NAD+ changes within 5 days. Most members report noticeable shifts in energy and mental sharpness within the first two weeks of Phase 1. Physical recovery, sleep quality and metabolic changes build over 60 to 90 days. Your practitioner will help you track what is changing.

How is this different from NMN or NR supplements?

NMN and NR are precursor molecules that require multi-step enzymatic conversion before becoming NAD+. Those pathways are rate-limited and decline with age. LathMized™ is a first-in-class intracellular NAD platform designed to support intracellular NAD+ levels directly, via mucosal absorption, rather than relying on precursor conversion. In the RENEWAL-NAD+ double-blind RCT (NCT07336836), oral administration resulted in a 53% intracellular NAD+ increase within 5 days while blood plasma NAD+ was unchanged — consistent with cellular, rather than circulatory, delivery.

Why is Phase 1 only 10 days?

The Longevity Protocol uses 1,500mg/day sipped hourly — which achieves rapid cellular repletion in a shorter window compared to lower-dose protocols. The RENEWAL-NAD+ trial showed measurable change within 5 days at this intensity. Phase 2 then transitions to daily tablet maintenance to sustain those levels indefinitely. Your practitioner may adjust timing based on your individual review.

Do I need to take this forever?

Phase 2 is ongoing daily maintenance — one 100mg sublingual tablet each morning. NAD+ naturally declines with age, so ongoing supplementation sustains what Phase 1 achieves. Most members continue indefinitely as part of their longevity practice. If you stop, NAD+ levels will gradually return to their pre-protocol baseline over time.

Is this safe alongside my existing supplements?

NAD+ at these doses is generally well-tolerated. The RENEWAL-NAD+ trial recorded zero serious adverse events across 60 participants. Your Harmover practitioner will review your current supplement stack and any medications at the assessment stage to confirm suitability for your specific situation.

Is this a prescription product?

LathMized™ NAD+ is a dietary supplement — not a prescription product. No GP referral is needed to register. Harmover's practitioner review is built into membership because the dosing is specific and clinically informed — it takes under 24–48 hours and is what makes this supervised rather than self-prescribed.

Important information

Before you begin

Please read

This is a wellness and nutritional programme — not a medical treatment and not intended to diagnose, treat, cure, or prevent any disease. If you are managing a health condition or taking medication, consult your GP before starting. Please disclose all current medications and supplements during registration so your practitioner can review appropriately. LathMized™ NAD+ at these doses is generally well-tolerated; your practitioner will confirm suitability for your specific situation.

Ready to begin?

Ready to see what NAD+ actually does for you?

Register free, go through your practitioner review, and receive your full longevity protocol. Most members notice a difference within the first two weeks. The deeper benefits compound over months.

Free to register · No commitment · Ships UK · EU · US · Canada

Reviewed by

Harmover Wellness Coach Team · April 2026

RENEWAL-NAD+ preprint ↗ ClinicalTrials.gov ↗ About our team ↗

LathMized™ NAD+Longevity Protocol